A student of Duilio Cambellotti at the Academy of Fine Arts in Rome, he was a leading exponent of Futurism and had close contacts with representatives of the European artistic avant-garde, with Dadaism with the Section d'Or, the Bauhaus, De Stijl, the Abstraction-Création group, with Pablo Picasso, Piet Mondrian, Wassily Kandinsky and Jean Cocteau, operating theoretically and practically also in the architecture sector.

In the middle of the decade (1910s), together with Balla and Fortunato Depero, he was the protagonist of the turning point of Roman futurism in the direction of a synthetic analog abstraction, perfectly exemplified by the words of the Manifesto of the futurist reconstruction of the universe of March 1915, signed by Balla and Depero.
Exhibition
Enrico Prampolini. Taccuini inediti 1942-1956, Modena, Galleria Civica, Palazzina dei Giardini, 24 November 1991 - 19 January 1992, cat. pp. 201, 202, n. PC 14, illustrated.